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Lesson Plan and Activity Finder

Find FREE science- and standards-based classroom lessons and multimedia activities on teens and drugs – all funded or created by NIDA.
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A Dangerous Mix

A Dangerous Mix

June 2019

In this lesson, developed in partnership with Scholastic, students will get an understanding of the unexpected and potential dangerous effects associated with mixing medications and over the counter drugs. Includes an adapted version for grades 4-6 reading level. 

Grade: 6-12



October 2015

Three lesson plans explore the disease of addiction and the changes that take place in the brain. Students test the effects of alcohol on the roundworm in a laboratory experiment, play a card game that models the unknown potential for individual addiction, and investigate how neurons change their connectivity when exposed to the drug morphine.

Grade: 6-12

D'Scerner: Critical Thinking of Opioid Study

D'Scerner: Critical Thinking of a Study: Opioids: Prescribing Patterns and Overdose-Related Deaths

October 2015

Students develop critical thinking skills as they analyze and evaluate scientific explanations about patterns in prescribing opioid pain medicines and deaths related to overdose. They learn the process of creating a scientific study to understand how science works and compare and contrast their analysis with that of traditional media articles. This is one lesson of the seven-part curriculum Transforming Science for Critical Thinkers.

Grade: 6-8

Drugs and Health Blog: Prescription Pain Medications (Opioids)

Drugs and Health Blog: Prescription Pain Medications (Opioids)

August 2016

Timely blog posts feature emerging trends and apply the science of drug abuse to real life. The teacher’s guide features classroom activities and discussion questions for use with selected posts to encourage students to think critically about how drugs and drug abuse can affect them.

Grade: 6-10

Mind Matters: The Brain's Response to Opioids

Mind Matters: The Body's Response to Opioids

November 2019

A visually appealing booklet for students that explains how prescription pain medicines, opioids, change the way the communication centers in the brain work and ultimately cause their effects. This booklet is part of a series focused on easy-to-understand scientific facts.

Grade: 5-9

Operation Prevention

April 2018

Students are introduced to the science behind opioids. The elementary school lessons explore over-the-counter and prescription medications, how medications work in our bodies, and why is it important to use them responsibly. The two middle school lessons explore the brain and body; the high school lessons explore the signs, symptoms, and science of opioid use. The resource includes virtual field trips, parent resources, and a video challenge.

Grade: 3-12

Opioids and the Overdose Epidemic pill bottle

Opioids and the Overdose Epidemic

March 2017

In this lesson, developed in partnership with Scholastic, students learn about the serious health crisis involving opioid drugs as well as what is causing it. They also learn that while prescription opioid pain medications can play an important role in a person’s medical care, the medications need to be used with extreme care. 

Grade: 6-12

Opioids: What You Need to Know

April 2020

In this lesson, developed in partnership with Scholastic, students will learn what opioids are, their potential dangers, and how to use opioids safely. 

Grade: 6-12