Can You Become Addicted to a Drug if You Just Take It Once?

If you take a drug one time and one time only, then you will not become addicted. The problem is that there is a lot we still don't know about who becomes addicted and why, and how much drug exposure it takes. We do know that each person is different, so it's a little like playing “Russian Roulette” if you choose to use drugs. But, if you do, the earlier you stop, the more likely you will be to avoid addiction and the harmful brain changes that lead to it.