These questions were answered by more than 50 individual scientists and science writers with expertise in addiction. To get as many answered as possible, responses were written quickly based on the personal background and knowledge of each expert. Please note that there was not a secondary review or proofreading of each fact, and if readers have questions or comments about any response, they can ask further questions.

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Can you OD on acid?

-Deeltus, Oregon

Acid (LSD) is a very powerful drug. As for overdosing, it depends on what you mean by that. It is very difficult to kill yourself with LSD in terms of overdosing, but you can certainly have extremely serious effects on your cognition, mood, and perception, which can be very disturbing and unpleasant, and can last for a long time after you've taken LSD. Check out this link for more information:

-Shwe Gyaw

Can you OD on ACID?

-Deeltus, Oregon

Hello Deeltus,
In theory you can OD on any drug. Acid or LSD is especially dangerous because it alters your perception of reality, so you can put yourself in danger or possibly hurt or kill someone else if you are driving while you are under the influence of this drug. Even if you do not OD, these drugs are made in unregulated illegal labs and so they can have toxic chemicals that can cause health problems. Some people experience "bad trips" where they have anxiety or panic while having disturbing hallucinations.

-Kristen Huntley

Can you OD on marijuana?

-BGCN-Nowata, Oklahoma

Hello BGCN - Nowata! Thanks for participating in Chat Day! Information about what can happen if you use marijuana can be found at the link here: Marijuana intoxication can, in rare cases, produce a temporary psychosis. There are no reports of people fatally overdosing (dying) on marijuana alone. However, people can feel some very uncomfortable side effects, especially when using marijuana with high THC levels. There are reports of marijuana users seeking treatment in emergency rooms, reporting unease and shaking, anxiety, paranoia, or hallucinations, and in rare cases, extreme psychotic reactions. Learn more about drug overdoses among youth. However, marijuana use can increase risks for accidents and injuries (impacts of drugged driving are discussed here: We hope this is helpful!

-Dave Thomas

Can you over dose on Ibuprofen??

-Kaden, California

Yes, you can take too much ibuprofen. Taking too much can lead to stomach and intestinal damage, including severe GI bleeding which can even be fatal. Always follow the instructions included with over the counter medications when taking them.

-Marsha Lopez

can you over dose on marijuana and if you use it for pain and can it hurt u in anyway other way then affecting your lungs

-Tas, Montana

Hello Tas,
In theory you can overdose on any drug. The availability of increasingly potent marijuana and edible forms and oil extracts make this more likely. In fact, there has been an increase in accidental poisonings of infants and pets with these products. Risk of overdose is independent of the purpose it is being used for. We don't know all of the ways that the many chemicals in marijuana may affect the brain and other organs, we know that some of the active chemicals are fat soluble, so they accumulate in the brain and other fatty tissues and is release over time. For more information, see:

-Shwe Gyaw

Can you overdose and die on advil

-Nugget BOI, Oregon

Its rare but can happen. Can damage your stomach or intestines.

-Tisha Wiley

Can you get addicted to smoking marijuana?

-Jovia, California

Hi Jovia,
This is a great question. YES. Cannabis products (marijuana, oils, waxes) can be addictive. When people get addicted to cannabis, they end up spending a lot of time using cannabis, keep using it even if it causes health problems (like a bad cough or asthma), need to increase the amount they use to get high and may have withdrawal symptoms when they stop or cut down on cannabis. This means that when they try to quit or reduce their usage, they may have trouble sleeping or concentrating, have a bad mood, or have trouble sleeping, and may have major cravings to use again. Here's a link to some information about cannabis that you may find helpful.

-Wilson Compton

can you get addicted to vape if you only try it?


Thanks for your question! We have seen lots of questions about vaping! We still don't know all the effects of vaping because they haven't been around as long as "combustible" cigarettes. One thing we worry about with vaping is that they may lead to nicotine addiction and this might cause some people to start using regular cigarettes, which can cause cancer. Check out these resources on e-cigs – There is a lot we still don't know about who becomes addicted and why, and after how much drug exposure. We do know that each person is different, so it's a little like playing “Russian Roulette” if you choose to use drugs. But, if you do, the earlier you stop, the more likely you will be to avoid addiction and the harmful brain changes that lead to it.

-Mary Kautz

Can you get addicted to Vaping?

-Wiley Wildcat, Illinois

Hi again Wiley Wildcat. The answer to your question is Possibly. Most e-cigs contain nicotine, and often they are able to deliver as much nicotine to the person who vapes as someone would get from smoking a cigarette. Nicotine is a highly addictive chemical, so the e-cig user could become addicted. Unless the person who vapes is using e-cigs to help them stop their smoking habit, e-cigs should be avoided. The teen years are critical for brain development, which continues into young adulthood. Nicotine affects the development of the brain's reward system, so continued e-cigarette use can lead to nicotine addiction.

-Kevin Walton

Can you get effects from second-hand inhaling juuls

-favianberganza, North Carolina

Thank you for joining us, favianberganza! Many of the chemicals, such as propylene glycol, glycerin, nicotine, chemical flavorings, and others, in the Juul liquid are still present in the vapor. If you have asthma or other respiratory conditions, inhaling the secondhand vapor may make your symptoms worse. Use this opportunity to talk to the people around you about protecting their health AND yours by quitting using Juuls. To learn more about tobacco, nicotine and e-cigs, see

-Aaron White

can you get hi on salvia?


Great question!

The effects of salvia are not well studied. You can learn more about what we do know about Salvia here:

-Vani Pariyadath

can you get high from eating weed if so will it make your breath smell bad

-GW, Maryland

Hi GW! This is an interesting question. In states that have legalized marijuana, there are stores that sell "edibles" which can come in all types of candies and baked goods. Eating these products do cause a high, however, it is easy to eat too much, because it takes longer to feel the effects. That has put a lot of people into the emergency room with bad symptoms, especially children. There has been at least one death of a toddler reported because the parents left edibles around the house, and the toddler ate them. "high". Smoking marijuana probably causes your breath to smell worse than edible marijuana.

-Michelle Leff

Can you get high off of elmer's glue?

-Chapoopoo, Illinois

Hi Chapoopoo
I think that elmer's is water based. so i think it's unlikely. The closer to an industrial strength glue you get the more dangerous it is. It is a bad idea to huff any volatile solvent.

stay healthy

-Ruben Baler

Can you get high off of huffing gasoline?

-Superdood, Illinois

Thanks for your question Superdood. Gasoline is a household item that can be aubused by hudding/sniffing. It can produce hallucinatory effects and (not to mention hazardous effects too) on your brain and body. Here is link to learn more about inhallants:

-Steve Gust

can you get high off of huffing paint?

-wave check 1, Illinois

Hi Wave,
Yes, Huffing paint can deprive your brain of oxygen and can damage your brain, but can also make you light headed which some call a "high."

-Dave Thomas

Can you get high off of Ibuprofen pills?

-IO, Florida

Hi there. No. You can't get high from taking ibuprofen. However, you can be pretty sure that taking too much of anything is not safe. Ibuprofen is a nonsteroidal anti-inflammatory drug, or NSAID. These drugs are very good at fighting fevers and relieving pain from arthritis, injuries, etc. Taking too many Ibuprofen can cause serious side effects, including kidney failure or stomach ulcers and bleeding.

-Roger Sorensen

can you get high off of sniffing sharpie?

-El Chapo, Illinois

Good question, El Chapo. Products like felt-tip markers, spray paints, glues, and cleaning fluids contain dangerous substances with mind-altering properties when inhaled. People don't typically think of these products as drugs because they are not intended for getting high, but some people use them for that purpose. When they do, these substances are called inhalants. Inhalants are mostly used by young kids and teens and are the only class of substance used more by younger than by older teens. Inhalants can cause slurred speech, lack of coordination and dizziness, as well as brain and organ damage, seizures, coma, and even death.

-Bethany Deeds

can you get high off of whipped cream bottles

-gabi, New Hampshire

Hi Gabi. Inhalant gases can be found in household or commercial products including whipped cream dispensers. When someone uses a whipped cream bottle to inhale these gases, the lungs absorb chemicals into the bloodstream sending them throughout the brain and body. Regular use of inhalants can cause serious harm to vital organs and systems besides the brain. Damage to these organs is not reversible even when the person stops abusing inhalants. Keep your body and brain safe and don't try inhalants!

-Katia Howlett

Can you get high off sharpies?

-Kevin, Illinois

Dear Kevin, Maybe you could get high on sharpies but why? Spend your time doing something really fun and cool like playing music, participating in a sport, acing a test at school, or volunteering in your community. More information on drug use and teens can be found at:

-Redonna Chandler

Does medical marijuana actually helpful or are doctors just handing it out.

-Bshields, Montana

Thats a good question. The U.S. Food and Drug Administration (FDA) has not approved marijuana for any medical uses; the FDA has approved several components of marijuana for medical use, however, just not the whole plant. The distribution of "medical" marijuana in the states that have approved it is being done on very little scientific evidence. We'll see whether -- and if so, how -- good clinical research shows the many purported benefits of marijuana to be true.

-Aaron White

Does medical marijuana still have the same effects of non-medical marijuana

-Brevin Tating, California

Depends--people mean a lot of different things when they talk about "medical marijuana". If they are talking about products that contain high levels of THC (the ingredient that gets you high), then there's no real difference. But some people are talking about products that are high in cannabidiol (CBD) and have no or almost no THC in them. These are the products that are being used to treat seizures, e.g., in children. CBD is a very different chemical and doesn't seem to have many of the same risks as THC--its not addictive, doesn't mess with your memory, etc. The problem with CBD products that are widely available is that they are not Federally regulated and you risk getting something that is not what you think it is or that has not be manufactured safely. The exception is a recently approved medication (Epidiolex), for treating seizure disorders in children.

-Susan Weiss

does mixing diferent kinds of drugs affect my body in a different way than if i use them separately

-dj nini,

Hi dj nini! Yes, that can definitely happen. Different kinds of drugs affect different parts of the body - some may affect one organ or another and some affect many all at once. Sometimes mixing drugs can intensify their effects on one organ system or make you not aware of the effects on others. For example, alcohol is a depressant that can cause you to feel sleepy. When alcohol is mixed with caffeine, the caffeine can mask the depressant effects of alcohol, making you feel more alert and awake than you would if you were only drinking alcohol. As a result, you may drink more alcohol and become more impaired than you realize, increasing your risk of a lot of negative consequences.

-Michelle Jobes

Does nicotine affect athletic play for better or worse? I have teammates that are all juuling before games and telling all of us who don't, that we should do it, because it helps their game and would help ours- they think they are faster and more accurate.. I thought they played worse than normal in our last tournament and we got a lot of "conduct calls" from them mouthing off on the field.

-madchrist7, California

This is a great question, madchrist7! When nicotine enters the body, it initially causes the adrenal glands to release a hormone called adrenaline. The rush of adrenaline stimulates the body and causes an increase in blood pressure, heart rate, and breathing, which may be why your teammates think they are performing better. However, long-term brain changes brought on by continued nicotine exposure from tobacco products, such as Juul, result in addiction. A person can develop tolerance to nicotine, which means that he/she no longer responds to the drug in the way that person initially responded and needs more nicotine to get the same effect. When a person tries to quit, he or she may have withdrawal symptoms, including:irritability, problems paying attention, trouble sleeping, increased appetite, and powerful cravings for tobacco. To learn more about tobacco, nicotine and e-cigs, see

-Shwe Gyaw

Does people under 18 years old shouldn't drink because of health issues or because of responsibility and immatureness


The teenage years are a time to learn how to have fun and cope with life in healthy ways. It is also a time of intense brain development. It's best to avoid alcohol until the legal age of 21 to allow the brain to reach its full potential. The chances of developing problems with alcohol are much lower when people wait until the legal age to drink. NIAAA's Underage Drinking fact sheet has more info:

-Emily Einstein

does redbull and cocaine fix your problems

-MG, Montana

Hi mg
hardly. for starters, redbull is legal and if you drink it responsible it's unlikely to fix your problems (although I don't know what your probelms are) or create serious ones. ON the other hand, cocaine is illegal and it can definitely get you into a whole lot of trouble.

-Shwe Gyaw

does second-hand smoking have the same effects as smoking?

-kelly, Arizona

Hi kelly,

There are real risks linked to exposure to secondhand smoke. Every year tens of thousands of Americans die from exposure to secondhand smoke. And those exposed risk some of the other diseases that smokers can suffer from.

The good news is that we are seeing the lowest record rates of smoking in teens and adults. The bad news is that each year almost 500,000 Americans die prematurely from tobacco use...and almost all of that is from firsthand and secondhand exposure to cigarette smoke.

-Mitch Zeller

does smoking affects concentration?


Smoking what? Marijuana certainly affects concentration and makes it difficult to learn new things and remember them. Tobacco--less so, but it has other health risks as I'm sure you are very aware.

-Aaron White

El Sueve pasa a liguilla?????


no se. vos que pensas?

-Ruben Baler

ELLLOOOOO. Okay so I see stars are very hard to obtain. I get that. Smh. BUT, what effects do drugs have to the body and mind when driving. Do certain ones make you more impaired than others? What do you do if you are in a situation where the driver is on some type of drugs and they are beginning to not be able to drive.

-Georgiana, Illinois

Georgiana - great question! Almost all drugs that are not prescribed by a doctor can affect the brain in ways that make driving unsafe--including marijuana, opioids, cocaine, amphetamine, benzodiazepines, etc. To drive a care safely, your balance, motor skills, coordination, perception, ability to pay attention, reaction time, and judgment must all be in good working order. Drugs may impair all of them, even when taken in small amounts. Don't get in the car with someone who is using a drug. If you are already in the car, see if you can tactfully encourage them to pull over.

-Amy Goldstein

Exactly how many diseases does alcohol cause?

-DS, Florida

The World Health Organization estimates that alcohol causes or contributes to more than 200 diseases and types of injuries. By their calculations, alcohol is responsible for 6 out of every 100 deaths worldwide each year. That adds up to more than 3 million people.

-Dave Thomas