Drugs & Health Blog

Tolerance, Dependence, Addiction: What's the Difference?

The NIDA Blog Team

Many people think drug addiction, dependence, and tolerance are pretty much the same thing. But in fact, each term means something very different about how drugs affect a person’s body and brain. Learning the difference is important.

Tolerance

Tolerance happens when a person no longer responds to a drug in the way they did at first. So it takes a higher dose of the drug to achieve the same effect as when the person first used it. This is why people with substance use disorders use more and more of a drug to get the “high” they seek.

Dependence

Dependence means that when a person stops using a drug, their body goes through “withdrawal”: a group of physical and mental symptoms that can range from mild (if the drug is caffeine) to life-threatening (such as alcohol or opioids, including heroin and prescription pain relievers). Many people who take a prescription medicine every day over a long period of time can become dependent; when they go off the drug, they need to do it gradually, to avoid withdrawal discomfort. But people who are dependent on a drug or medicine aren’t necessarily addicted.

Addiction

Unlike tolerance and dependence, addiction is a disease; but like tolerance and dependence, addiction can result from taking drugs or alcohol repeatedly. If a person keeps using a drug and can’t stop, despite negative consequences from using the drug, they have an addiction (also called a severe substance use disorder). But again, a person can be dependent on a drug, or have a high tolerance to it, without being addicted to it.

See what teens are asking about tolerance, dependence, and addiction—and the answers—here.

Comments posted to the Drugs & Health Blog are from the general public and may contain inaccurate information. They do not represent the views of NIDA or any other federal government entity.

Comments

Doctors have a responsibility to warn patients of the possibility of dependence when they offer prescription drugs. This does not always happen.
I feel people shouldn't be experiments for science research especially if they aren't recieveing compensation for it and there are other ways to heal besides prescription drugs.
that is so true well done for thinking about other people in the world some drugs go from legal to illegal drugs
dont get it
neither
Really cool stuff guys
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be safe never do drugs

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