NIDA for Teens: The Science Behind Drug Abuse
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K2/Spice

“Spice” – Not as Fun as it Sounds

Spice—also known as K2, Fake Marijuana, Skunk, and other names—is a synthetic (or man-made) substance made from shredded dried plant materials and chemicals.  Spice appears to stimulate the same brain receptors—molecules that recognize specific chemicals and transmit messages into cells—as marijuana does and produces a similar “high.”

Like marijuana, Spice is usually abused by smoking, but it can be prepared as a drink.

Because Spice is marketed as being “natural,” some people may think it’s safe to use.  But the ingredients used to make Spice can vary, and no one’s watching to see what people producing Spice are using—meaning the results could have dangerous effects on your body and brain.  Some mixtures even contain harmful metal residues.

Nothing Nice

Spice is illegal in the United States and in most European countries.  The U.S. Naval Academy recently expelled seven midshipmen for using it.

Spice products are labeled “not fit for human consumption” and are illegal in the United States and most European countries. Its side effects, like the ingredients, often vary, but emergency rooms report seeing people with rapid heart rates, vomiting, agitation, and hallucinations.

Using Spice can lead to abuse and even addiction as the body builds up tolerance to the drug’s effects over time and craves a higher dose to achieve the same effect.

So, SBB’s recommendation?  Get your highs the natural way: exercise, friends, music, whatever you like to do—without altering your brain’s chemistry!

A picture of synthetic marijuana.

Spice: "If You Use It, You're Experimenting on Yourself"

Ask NIDA scientist Marilyn A. Huestis, Ph.D., what she wants to tell young people about the synthetic (manmade) marijuana called Spice, and she responds with passion. In a recent interview with SBB, Dr. Huestis shared a news story about teens in Dallas who went to the ER with chest pains, only to learn that they had had heart attacks. All of them had recently smoked Spice.

Dr. Huestis said that dangerous health effects from Spice are possible because of the drug’s potency. “Using Spice is very dangerous because the chemicals and compounds that are in it vary from batch to batch. You might buy a package one week, go back to the same place and buy the exact same package the next week, and the ingredients may be completely different. Not only are the ingredients unknown, but so is the strength of the drug,” she said.

“Because its makeup varies so widely, studying Spice is a challenge,” said Dr. Huestis. “Essentially, if you use it, you’re experimenting on yourself.”

That experimentation could result in other life-threatening health complications. According to a recent news story out of Wyoming, three young people were hospitalized with kidney failure from using blueberry-flavored Spice. A dozen other people got sick. Everyone affected was in their late teens or early 20s.

Use Is Expanding

NIDA’s Monitoring the Future study asked teens about synthetic marijuana for the first time in the 2011 survey. What they found: Approximately 1 in every 10 high school seniors reported use in the past 12 months. Teens and young adults may be drawn to Spice because sometimes it comes in flavors.

Even though it’s illegal in the United States, Spice is still available in some truck stops and other places that market it as incense. Dr. Huestis said this is because manufacturers are constantly changing the ingredients to attempt to get around the bans. However, the United States does have an “analog law,” which bans drugs with chemistry and effects similar to illegal drugs.

“We’re learning more about Spice and how it works in the body and brain every day,” said Dr. Huestis. “Research is focusing on the body’s cannabinoid system, which regulates hunger, memory, and heart rate, among many other important functions. Spice and marijuana hijack this system.”

Read more about Spice.

Girl holding chest